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Test Code COKEM Cocaine and Metabolites Confirmation, Meconium

Reporting Name

Cocaine and Metabolites, Confirm, M

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Detecting in utero drug exposure up to 5 months before birth

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)


Ordering Guidance


For chain-of-custody testing, order COKMX / Cocaine and Metabolite Confirmation, Chain of Custody, Meconium.



Specimen Required


Supplies: Stool container, Small (Random), 4 oz (T288)

Container/Tube: Stool container

Specimen Volume: 1 g (approximately 1 teaspoon)

Collection Instructions: Collect entire random meconium specimen.


Specimen Type

Meconium

Specimen Minimum Volume

0.3 g (approximately 1/4 teaspoon)

Specimen Stability Information

Specimen Type Temperature Time
Meconium Frozen (preferred) 21 days
  Refrigerated  21 days
  Ambient  72 hours

Reject Due To

Grossly bloody Reject; Pink OK
Stool;
Diapers		 Reject

Reference Values

Negative

 

Positive results are reported with a quantitative liquid chromatography tandem mass spectrometry (LC-MS/MS) result.

 

Cutoff concentrations for LC-MS/MS testing:

Cocaine: 20 ng/g

Benzoylecgonine: 20 ng/g

Cocaethylene: 20 ng/g

m-Hydroxybenzoylecgonine: 20 ng/g

Interpretation

The presence of any of the following: cocaine, benzoylecgonine, cocaethylene, or m-hydroxybenzoylecgonine, at 20 ng/g or more, is indicative of in utero drug exposure up to 5 months before birth.

Day(s) Performed

Monday through Sunday

Report Available

2 to 3 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

G0480

80353 (if appropriate for select payers)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
COKEM Cocaine and Metabolites, Confirm, M 69008-1

 

Result ID Test Result Name Result LOINC Value
31859 Cocaine 69009-9
31860 Benzoylecgonine 69010-7
31861 Cocaethylene 69011-5
31862 m-Hydroxybenzoylecgonine 69012-3
31864 Interpretation 69050-3
31865 Chain of Custody 77202-0

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.