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Test Code CRITH DNA Double-Stranded (dsDNA) Antibodies by Crithidia luciliae IFA, IgG, Serum

Reporting Name

dsDNA Ab by Crithidia IFA, IgG, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Confirmation testing for dsDNA IgG antibodies in patients with clinical features of systemic lupus erythematosus or at-risk for disease

 

This test should not be used independently for monitoring treatment response or establishing remission.

Method Name

Indirect Immunofluorescence


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.3 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Type

Serum

Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Reference Values

Negative

Interpretation

A positive result for double-stranded DNA (dsDNA) IgG antibodies in the appropriate clinical context is highly suggestive of systemic lupus erythematosus (SLE). The presence of dsDNA IgG antibodies detected using the Crithidia luciliae indirect immunofluorescence test is highly specific for SLE with moderate sensitivity.

 

A negative result does not exclude a diagnosis of SLE.

Day(s) Performed

Monday through Friday

Report Available

2 to 4 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86255

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CRITH dsDNA Ab by Crithidia IFA, IgG, S 58466-4

 

Result ID Test Result Name Result LOINC Value
62925 dsDNA Ab by Crithidia IFA, IgG, S In Process
37268 Crithidia Interpretation 69048-7