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Test Code DCP Des-Gamma-Carboxy Prothrombin, Serum

Reporting Name

Des-Gamma-Carboxy Prothrombin, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Risk assessment of patients with chronic liver disease for development of hepatocellular carcinoma (HCC)

 

Aiding in the monitoring of HCC patients post therapy if des-gamma-carboxy prothrombin (DCP) level was elevated prior to therapy

Method Name

Isotachophoresis with Laser-Induced Fluorescence

Specimen Type

Serum


Advisory Information


For diagnostic use, this test is most cost-effective for at-risk patients with normal levels of total and L3 alpha fetoprotein in serum. For more information see L3AFP / Alpha-Fetoprotein (AFP) L3% and Total, Hepatocellular Carcinoma Tumor Marker, Serum.



Specimen Required


Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL


Specimen Minimum Volume

0.2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 90 days
  Refrigerated  7 days

Reject Due To

Gross hemolysis Reject
Gross lipemia OK

Reference Values

<7.5 ng/mL

Interpretation

In patients with an elevated des-gamma-carboxy prothrombin (DCP) result (≥7.5 ng/mL), the risk of developing hepatocellular carcinoma (HCC) is 36.5% (95% CI 23.5%-49.6%). The risk of developing HCC with a negative DCP result (<7.5 ng/mL) is 7.6% (95% CI 4.4%-10.8%).

 

For patients with HCC and an elevated DCP level prior to therapy, an elevated DCP level posttherapy is associated with an increased risk of HCC recurring.

Day(s) and Time(s) Performed

Monday, Wednesday, Friday; 10 a.m.

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

83951

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DCP Des-Gamma-Carboxy Prothrombin, S 34444-0

 

Result ID Test Result Name Result LOINC Value
DCP Des-Gamma-Carboxy Prothrombin, S 34444-0