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Test Code DSM4X Drugs of Abuse Screen 4, Chain of Custody, Meconium

Reporting Name

Drugs of Abuse Screen 4, CoC, M

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Identifying amphetamines (and methamphetamines), opiates, as well as metabolites of cocaine and marijuana in meconium specimen

 

Chain of custody is required whenever the results of testing could be used in a court of law. Its purpose is to protect the rights of the individual contributing the specimen by demonstrating that it was always under the control of personnel involved with testing the specimen; this control implies that the opportunity for specimen tampering would be limited. Since the evidence of illicit drug use during pregnancy can be cause for separating the baby from the mother, a complete chain of custody ensures that the test results are appropriate for legal proceedings.

Method Name

Competitive Chemiluminescent Immunoassay (CIA)


Specimen Required


Container/Tube: Chain of Custody Meconium Kit (T653) includes the specimen containers, seals, and documentation required.

Specimen Volume: 1 g (approximately 1 teaspoon)

Collection Instructions: Collect entire random meconium specimen.

Additional Information:

1. Specimen that arrives with a broken seal does not meet the chain-of-custody requirements.

2. The laboratory recommends sending chain-of-custody specimens by overnight shipment.


Specimen Type

Meconium

Specimen Minimum Volume

0.45 g (approximately 0.5 teaspoon)

Specimen Stability Information

Specimen Type Temperature Time Special Container
Meconium Frozen (preferred) 21 days
  Refrigerated  21 days
  Ambient  72 hours

Reject Due To

Grossly bloody Reject, Pink OK

Reference Values

Negative

 

Positive results are reported with a quantitative liquid chromatography tandem mass spectrometry result.

 

Cutoff concentrations by competitive chemiluminescent immunoassay:

Amphetamines: 100 ng/g

Methamphetamine: 100 ng/g

Benzoylecgonine (cocaine metabolite): 100 ng/g

Opiates: 100 ng/g

Tetrahydrocannabinol carboxylic acid (marijuana metabolite): 20 ng/g

Interpretation

The limit of quantitation varies for each of these drug groups.

-Amphetamines: >100 ng/g

-Methamphetamines: >100 ng/g

-Cocaine and metabolite: >100 ng/g

-Opiates: >100 ng/g

-Tetrahydrocannabinol carboxylic acid: >20 ng/g

Day(s) Performed

Monday through Saturday

Report Available

1 to 2 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80307

80324 (if appropriate)

80359 (if appropriate)

80353 (if appropriate)

80361 (if appropriate)

80365 (if appropriate)

80349 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DSM4X Drugs of Abuse Screen 4, CoC, M 49046-6

 

Result ID Test Result Name Result LOINC Value
36172 Amphetamine 26895-3
36173 Methamphetamine 27289-8
36174 Cocaine 26956-3
36175 Opiate 29158-3
36176 Tetrahydrocannabinol 26893-8
36177 Chain of Custody 77202-0

Forms

1. Chain of Custody Request is included in the Chain of Custody Kit (T282)

2. If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.

Additional Tests

Test ID Reporting Name Available Separately Always Performed
COCH Chain of Custody Processing No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
COKMX Cocaine and metabolite Conf, CoC, M Yes No
OPTMX Opiate Confirmation, CoC, M Yes No
THCMX Carboxy-THC Confirmation, CoC, M Yes No
AMPMX Amphetamines Confirmation, CoC, M Yes No

Testing Algorithm

Testing begins with immunoassay screen. Positive results are confirmed and quantitated by liquid chromatography tandem mass spectrometry at an additional charge.