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HelpTest Code GAES Ganglioside Antibodies Evaluation, Serum
Specimen Required
Patient Preparation: For optimal antibody detection, specimen collection is recommended to occur prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Forms
If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.
Useful For
Supporting the diagnosis of an autoimmune neuropathy
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| GAESI | Ganglioside Antibodies Interp, S | No | Yes |
| GQ1ES | GQ1b-IgG ELISA, S | Yes | Yes |
| IGG_D | IgG Disialo. GD1b | No | Yes |
| IGM_D | IgM Disialo. GD1b | No | Yes |
| IGG_M | IgG Monos. GM1 | No | Yes |
| IGM_M | IgM Monos. GM1 | No | Yes |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IGDTS | IgG Disialo GD1b Titer, S | No | No |
| IMDTS | IgM Disialo GD1b Titer, S | No | No |
| IGMTS | IgG Monos GM1 Titer, S | No | No |
| IMMTS | IgM Monos GM1 Titer, S | No | No |
Testing Algorithm
Screening tests are performed for IgG and IgM antibodies to gangliosides GM1 and GD1b. If positive, the appropriate titer will be performed at an additional charge.
For more information see:
Method Name
GQ1ES, IGG_D, IGM_D, IGG_M, IGM_M, IGDTS, IMDTS, IGMTS, IMMTS: Enzyme-Linked Immunosorbent Assay (ELISA)
GAESI: Technical Interpretation
Reporting Name
Ganglioside Antibodies Eval, SSpecimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 72 hours |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Reference Values
GQ1b-IgG ELISA: Negative
IgG Disialo. GD1b: Negative
IgM Disialo. GD1b: Negative
IgG Monos. GM1: Negative
IgM Monos. GM1: Negative
IgG Disialo GD1b Titer: <1:2000
IgM Disialo GD1b Titer: <1:2000
IgG Monos GM1 Titer: <1:2000
IgM Monos GM1 Titer: <1:4000
Interpretation
High titers (>1:8000) favor the diagnosis of multifocal motor neuropathy or multifocal acquired demyelinating sensory and motor (MADSAM) neuropathy over motor neuron disease. About 30% to 50% of patients with these clinical syndromes or the pure motor variant of chronic inflammatory demyelinating polyneuropathy have ganglioside autoantibodies. High-antibody titers appear to be a specific, but not sensitive, marker of these related disorders.
Day(s) Performed
Monday, Wednesday, Friday
Report Available
5 to 8 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83516 x5
83520 x4 (if applicable)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| GAES | Ganglioside Antibodies Eval, S | 82455-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 621107 | GQ1b-IgG ELISA, S | 63254-7 |
| 621109 | Ganglioside Antibodies Interpretation, S | 69048-7 |
| 4416 | IgG Disialo. GD1b | 94868-7 |
| 4412 | IgG Monos. GM1 | 63243-0 |
| 4417 | IgM Disialo. GD1b | 94870-3 |
| 4413 | IgM Monos. GM1 | 63247-1 |