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Test Code GLIC CD8 T-Cell Immune Competence, Global, Blood

Reporting Name

CD8 Immune Competence, B

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Determining overimmunosuppression within the CD8 T-cell compartment, when used on transplant recipients and patients with autoimmune disorders receiving therapy with immunosuppressant agents

Method Name

Flow Cytometry


Shipping Instructions


Testing performed Monday through Friday. Specimens not received by 4 p.m. Central time on Friday may be canceled.

 

Samples arriving on the weekend and observed holidays may be canceled.

 

Collect and package specimen as close to shipping time as possible. Ship specimen overnight in an Ambient Shipping Box-Critical Specimens Only (T668) following the instructions in the mailer.

 

It is recommended that specimens arrive within 24 hours of collection.



Necessary Information


Ordering healthcare professional name and phone number are required.



Specimen Required


Supplies: Ambient Shipping Box-Critical Specimens Only (T668)

Container/Tube: Green top (sodium heparin)

Specimen Volume: 15 mL

Collection Instructions: Send whole blood specimen in original tube. Do not aliquot.


Specimen Type

WB Sodium Heparin

Specimen Minimum Volume

10 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
WB Sodium Heparin Ambient 48 hours GREEN TOP/HEP

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject

Reference Values

Interferon-gamma (IFN-gamma) expression (as % CD8 T cells): 10.3-56.0%

 

CD107a/b expression (as % CD8 T cells): 8.5-49.1%

 

Reference values have not been established for patients who are <19 years of age.

Interpretation

Interferon-gamma (IFN-gamma) and CD107a and CD107b expression below the defined reference range are consistent with a global impairment in CD8 T-cell function, most likely due to overimmunosuppression.

 

The IFN-gamma and CD107a and CD107b levels greater than the defined reference range are unlikely to have any clinical significance.

Day(s) Performed

Monday through Friday

Report Available

3 to 6 days

Test Classification

This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86356 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
GLIC CD8 Immune Competence, B 80222-3

 

Result ID Test Result Name Result LOINC Value
30643 IFN-g 95204-4
30644 CD107a/b 95203-6
30645 Interpretation 69052-9