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HelpTest Code GQ1ES Ganglioside GQ1b Antibody, IgG, ELISA, Serum
Necessary Information
Provide the following information:
1. Relevant clinical information
2. Ordering provider name, phone number, mailing address, and email address
Specimen Required
Patient Preparation: For optimal antibody detection, specimen collection is recommended to occur prior to initiation of immunosuppressant medication or intravenous immunoglobulin treatment.
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Red top
Acceptable: Serum gel
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Useful For
Evaluating patients with an underlying demyelinating neuropathy
Supporting the diagnosis of a ganglioside GQ1b IgG-related disorder
Method Name
Enzyme-Linked Immunosorbent Assay (ELISA)
Reporting Name
GQ1b-IgG ELISA, SSpecimen Type
SerumSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 72 hours |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | Reject |
Reference Values
Negative
Interpretation
A positive result is consistent with an immune-mediated demyelinating neuropathy and correlation with clinical electrodiagnostic features is recommended.
Ganglioside GQ1b (GQ1b) IgG antibodies occur in Miller Fisher syndrome, Bickerstaff brainstem encephalitis, and atypical Guillain-Barre syndromes having variably present demyelinating neuropathy, ophthalmoplegia, ataxia, brainstem features with encephalitis and, less commonly, other neurogenic conditions.
A negative result does not exclude an immune-mediated demyelinating neuropathy nor a GQ1b IgG syndrome.
Day(s) Performed
Monday, Wednesday, Friday
Report Available
5 to 8 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83516
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| GQ1ES | GQ1b-IgG ELISA, S | 63254-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 621107 | GQ1b-IgG ELISA, S | 63254-7 |
Forms
If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.