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Test Code HCQ Hydroxychloroquine, Serum

Reporting Name

Hydroxychloroquine, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring serum hydroxychloroquine concentrations, assessing compliance, and adjusting dosage in patients

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (gel tubes/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Collect specimen immediately before next scheduled dose.

2. Within 2 hours of collection, centrifuge, and aliquot serum into a plastic vial.


Specimen Type

Serum Red

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  21 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

For suppressive treatment of malaria, suggested plasma or serum concentrations should be >10 ng/mL.

 

For systemic lupus erythematosus, proposed serum target concentrations should be ≥500 ng/mL.

Interpretation

The serum concentration should be interpreted in the context of the patient's clinical response and may provide useful information in patients showing poor response, noncompliance, or adverse effects. Concentrations less than 106 ng/mL have been associated with noncompliance.

Day(s) Performed

Monday, Wednesday, Friday

Report Available

3 to 7 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80220

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HCQ Hydroxychloroquine, S 3684-8

 

Result ID Test Result Name Result LOINC Value
64947 Hydroxychloroquine, S 3684-8

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.