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HelpTest Code HISER Histoplasma Antibody Complement Fixation and Immunodiffusion, Serum
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1.1 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial.
Useful For
Aiding in the diagnosis of active histoplasmosis
Testing Algorithm
For more information see Meningitis/Encephalitis Panel Algorithm.
Special Instructions
Method Name
Complement Fixation (CF)/Immunodiffusion (ID)
Reporting Name
Histoplasma Ab CompFix/ImmDiff, SSpecimen Type
SerumSpecimen Minimum Volume
See Specimen Required
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
Reference Values
Anti-Yeast Antibody by Complement Fixation:
Negative (positive results reported as titer)
Antibody by Immunodiffusion:
Negative (positive results reported as band present)
Interpretation
Complement fixation (CF) titer results of 1:32 or higher indicate active disease. A rising CF titer is associated with progressive infection.
Patients infected with Histoplasma capsulatum demonstrate a serum antibody with a rising titer within 6 weeks of infection. A rising titer is associated with progressive infection. Specific antibody persists for a few weeks to a year, regardless of clinical improvement.
The presence of H and/or M bands on immunodiffusion tests is considered a positive result for the presence of antibodies to Histoplasma. Presence of an H band suggests recent infection.
Day(s) Performed
Monday through Friday
Report Available
2 to 7 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86698 x2
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HISER | Histoplasma Ab CompFix/ImmDiff, S | 90227-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 621214 | Histoplasma Yeast CompFix, S | 20574-0 |
| 621215 | Histoplasma Immunodiffusion, S | 90232-0 |