Test Code HPFH Hemoglobin F Distribution, Blood
Reporting Name
Hb F Distribution, BPerforming Laboratory
Mayo Clinic Laboratories in RochesterUseful For
Distinguishing large deletional hereditary persistence of fetal hemoglobin from other conditions with increased percentage of fetal hemoglobin (Hb F)
Determining the distribution of Hb F within red blood cells
Method Name
Only orderable as a reflex. For more information see:
-HAEV1 / Hemolytic Anemia Evaluation, Blood
-HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood
-MEV1 / Methemoglobinemia Evaluation, Blood
-REVE2 / Erythrocytosis Evaluation, Blood
-THEV1 / Thalassemia and Hemoglobinopathy Evaluation, Blood
Flow Cytometry
Ordering Guidance
This test is for hereditary persistence of fetal hemoglobin only. For testing for possible fetal-maternal bleed, see FMB / Fetomaternal Bleed, Flow Cytometry, Blood.
Specimen Required
Only orderable as a reflex. For more information see:
-HAEV1 / Hemolytic Anemia Evaluation, Blood
-HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood
-MEV1 / Methemoglobinemia Evaluation, Blood
-REVE2 / Erythrocytosis Evaluation, Blood
-THEV1 / Thalassemia and Hemoglobinopathy Evaluation, Blood
Specimen Type
Whole Blood EDTASpecimen Minimum Volume
0.5 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Whole Blood EDTA | Refrigerated | 14 days |
Reject Due To
Gross hemolysis | Reject |
Gross lipemia | OK |
Clotted blood | Reject |
Reference Values
Only orderable as a reflex. For more information see:
-HAEV1 / Hemolytic Anemia Evaluation, Blood
-HBEL1 / Hemoglobin Electrophoresis Evaluation, Blood
-MEV1 / Methemoglobinemia Evaluation, Blood
-REVE2 / Erythrocytosis Evaluation, Blood
-THEV1 / Thalassemia and Hemoglobinopathy Evaluation, Blood
Reported as: Heterocellular, Homocellular, or Equivocal
Interpretation
Homocellular distribution of fetal hemoglobin (Hb) is found in large deletional hereditary persistence of fetal Hb.
Heterocellular distribution is found in delta beta thalassemia, medication induced, and other causes of increased Hb F.
An equivocal result indicates the pattern is not typical for either a homocellular or heterocellular distribution.
Day(s) Performed
Monday through Friday
Report Available
3 to 5 daysTest Classification
This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
88184
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
HPFH | Hb F Distribution, B | 4579-9 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
8270 | Hb F Distribution, B | 4579-9 |
2104 | Interpretation | 59466-3 |