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HelpTest Code HTLVC Human T-Cell Lymphotropic Virus Types 1 and 2 (HTLV-1/-2) Antibody Screen with Confirmation, Spinal Fluid
Reporting Name
HTLV-1/-2 Ab Screen, CSFPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Qualitative screening detection of human T-cell lymphotropic virus types 1 and 2 (HTLV-1/-2) specific antibodies with confirmation and differentiation between HTLV-1 and HTLV-2 infection
This test should not be used as a screening or confirmatory test for any specimen other than spinal fluid.
Method Name
Enzyme Immunoassay (EIA)
Ordering Guidance
This test is for cerebrospinal fluid specimens only. For serum specimens, order HTLVI / Human T-Cell Lymphotropic Virus Types I and II Antibody Screen with Confirmation, Serum.
Necessary Information
Date of collection is required.
Specimen Required
Collection Container/Tube: Sterile vial
Specimen Volume: 1 mL
Collection Instructions: Submit spinal fluid specimen from collection vial 1.
Specimen Type
CSFSpecimen Minimum Volume
0.6 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| CSF | Frozen (preferred) | 30 days | |
| Refrigerated | 14 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Heat-treated or precipitated specimen | Reject |
Reference Values
Negative
Interpretation
Negative screening results indicate the absence of both human T-cell lymphotropic virus types 1 and 2 (HTLV-1/-2)-specific IgG antibodies in spinal fluid.
A reactive screening test result is suggestive of infection with either HTLV-1 or HTLV-2. However, this result does not confirm infection (eg, low specificity), and it cannot differentiate between HTLV-1 and HTLV-2 infection.
Specimens with reactive screening test results will be tested automatically by the line immunoassay (LIA) confirmatory test. Positive LIA results provide confirmatory evidence of infection with HTLV-1 or HTLV-2.
A reactive screening result with a negative or indeterminate confirmatory test result suggests either a false-reactive screening test result or a seroconverting HTLV infection. Repeat testing in 1 to 2 months can clarify the final infection status. Persistently indeterminate confirmatory test results indicate absence of HTLV infection.
Day(s) Performed
Monday, Tuesday, Thursday, Friday
Report Available
1 to 4 daysTest Classification
This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
86790Â
86689 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HTLVC | HTLV-1/-2 Ab Screen, CSF | 22361-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 604934 | HTLV-1/-2 Ab Screen, CSF | 22361-0 |
Forms
If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| HTLLC | HTLV -1/-2 Ab Confirmation, CSF | Yes | No |
Testing Algorithm
If human T-cell lymphotropic virus types 1 and 2 (HTLV-1/-2) antibody is reactive, then HTLV-1/-2 antibody confirmation by line immunoassay will be performed at an additional charge.