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HelpTest Code HYOX Hyperoxaluria Panel, Random, Urine
Reporting Name
Hyperoxaluria Panel, UPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Distinguishing between primary and secondary hyperoxaluria
Distinguishing between primary hyperoxaluria types 1, 2, and 3
Method Name
Gas Chromatography Mass Spectrometry (GC-MS)
Necessary Information
1. Patient age is required.
2. Biochemical Genetics Patient Information (T602) is recommended, but not required, to be filled out and sent with the specimen to aid in the interpretation of test results.
Specimen Required
Supplies: Urine Tubes, 10 mL (T068)
Container/Tube: Plastic, 10-mL urine tube
Specimen Volume: 10 mL
Collection Instructions:
1. Collect a random urine specimen.
2. No preservative.
3. Immediately freeze specimen.
Specimen Type
UrineSpecimen Minimum Volume
1.1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Frozen (preferred) | 90 days | |
| Refrigerated | 14 days |
Reject Due To
All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.Reference Values
GLYCOLATE
≤17 years: ≤75 mg/g creatinine
≥18 years: ≤50 mg/g creatinine
GLYCERATE
≤31 days: ≤75 mg/g creatinine
32 days - 4 years: ≤125 mg/g creatinine
5 - 10 years: ≤55 mg/g creatinine
≥11 years: ≤25 mg/g creatinine
OXALATE
≤6 months: ≤400 mg/g creatinine
7 months - 1 year: ≤300 mg/g creatinine
2 - 6 years: ≤150 mg/g creatinine
7 - 10 years: ≤100 mg/g creatinine
≥11 years: ≤75 mg/g creatinine
4-HYDROXY-2-OXOGLUTARATE (HOG)
≤10 mg/g creatinine
Interpretation
Increased concentrations of oxalate and glycolate indicate type 1 hyperoxaluria.
Increased concentrations of oxalate and glycerate indicate type 2 hyperoxaluria.
Increased concentrations of oxalate and 4-hydroxy-2-oxoglutarate indicate type 3 hyperoxaluria.
Increased concentrations of oxalate with normal concentrations of glycolate, glycerate, and 4-hydroxy-2-oxoglutarate indicate secondary hyperoxaluria.
Day(s) Performed
Wednesday
Report Available
3 to 9 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82542
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| HYOX | Hyperoxaluria Panel, U | 53710-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 50592 | Glycolate | 13751-3 |
| 50593 | Glycerate | 13749-7 |
| 50594 | Oxalate | 13483-3 |
| 38049 | 4-hydroxy-2-oxoglutarate | 13678-8 |
| 29982 | Interpretation | 59462-2 |
| 29984 | Reviewed By | 18771-6 |
Forms
1. Biochemical Genetics Patient Information (T602)
2. If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-Biochemical Genetics Test Request (T798)
-Renal Diagnostics Test Request (T830)
Special Instructions
Testing Algorithm
For more information see Hyperoxaluria Diagnostic Algorithm.