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HelpTest Code MB2GP Beta-2 Glycoprotein 1 Antibodies, IgM, Serum
Reporting Name
Beta 2 GP1 Ab IgM, SPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Evaluating patients with suspected antiphospholipid syndrome by identification of beta-2 glycoprotein 1 IgM antibodies
First-line test when antiphospholipid syndrome is strongly suspected in conjunction with cardiolipin antibodies (IgG and IgM) and lupus anticoagulant testing
Estimating the risk of thrombosis and/or pregnancy-related morbidity in patients with systemic lupus erythematosus
Method Name
Enzyme-Linked Immunosorbent Assay (ELISA)
Additional Testing Requirements
Diagnostic criteria for antiphospholipid syndrome include the presence of at least one of the following: lupus anticoagulant, anticardiolipin, and anti-beta-2 glycoprotein 1 IgG or IgM antibodies. Consider ordering CLPMG / Phospholipid (Cardiolipin) Antibodies, IgG and IgM, Serum; GB2GP / Beta-2 Glycoprotein 1 Antibodies, IgG, Serum; and ALUPP / Lupus Anticoagulant Profile, Plasma concurrently with this test.
Specimen Required
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Type
SerumSpecimen Minimum Volume
0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 21 days | |
| Frozen | 21 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | OK |
| Heat-treated specimens | Reject |
Reference Values
<15.0 SMU (negative)
15.0-39.9 SMU (weakly positive)
40.0-79.9 SMU (positive)
≥80.0 SMU (strongly positive)
Results are reported in standard IgM anti-beta 2 glycoprotein 1 units (SMU).
Reference values apply to all ages.
Interpretation
Positive results for beta-2 glycoprotein 1 (B2GPI) IgM antibodies in association with specific clinical manifestations may be diagnostic for antiphospholipid syndrome (APS).
Compared to IgG antibodies B2GPI, the presence of isolated and low levels of B2GPI IgM antibodies have been reported to demonstrate a low risk for APS.
Documentation of persistent anti- B2GPI IgM antibodies is a requirement for the diagnosis of definite APS. Antibodies must be detected on 2 or more occasions at least 12 weeks apart to fulfill the laboratory diagnostic criteria for APS.
Detection of B2GPI antibodies using the enzyme-linked immunosorbent assay method or other solid-phase immunoassays is not affected by anticoagulant treatment.
Day(s) Performed
Monday through Saturday
Report Available
2 to 6 daysTest Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
86146
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| MB2GP | Beta 2 GP1 Ab IgM, S | 44449-7 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| MB2GP | Beta 2 GP1 Ab IgM, S | 44449-7 |