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HelpTest Code MDNS Methadone and Metabolites, Serum
Reporting Name
Methadone and Metabolite, SPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Compliance monitoring of methadone
Assessment of methadone toxicity
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Container/Tube: Red top (Serum gel/SST are not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 1.0 mL
Collection Instructions: Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
Specimen Type
Serum RedSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 14 days |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
Not established
Interpretation
There is a significant overlap between the reported therapeutic and toxic concentrations of methadone in blood specimens.
Day(s) Performed
Tuesday, Thursday
Report Available
3 to 5 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80299
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| MDNS | Methadone and Metabolite, S | 96602-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 36309 | Methadone | 3772-1 |
| 36310 | EDDP | 60071-8 |
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.