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HelpTest Code OPATM Opiate Confirmation, Meconium
Reporting Name
Opiate Confirmation, MPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Detecting maternal prenatal opiate/opioid use up to 5 months before birth
Method Name
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Ordering Guidance
For chain-of-custody testing, order OPTMX / Opiate Confirmation, Chain of Custody, Meconium.
Specimen Required
Supplies: Stool container, Small (Random), 4 oz (T288)
Container/Tube: Stool container
Specimen Volume: 1 g (approximately 1 teaspoon)
Collection Instructions: Collect entire random meconium specimen.
Specimen Type
MeconiumSpecimen Minimum Volume
0.3 g (approximately 1/4 teaspoon)
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Meconium | Frozen (preferred) | 28 days | |
| Refrigerated | 28 days | ||
| Ambient | 14 days |
Reject Due To
| Grossly bloody | Reject; Pink OK |
| Stool Diapers |
Reject |
Reference Values
Negative
Positives are reported with a quantitative liquid chromatography tandem mass spectrometry (LC-MS/MS) result.
Cutoff concentrations for LC-MS/MS testing:
Codeine: 20 ng/g
Hydrocodone: 20 ng/g
Hydromorphone: 20 ng/g
Morphine: 20 ng/g
Oxycodone: 20 ng/g
Oxymorphone: 20 ng/g
Interpretation
The presence of any of the following opiates (codeine, morphine, hydrocodone, hydromorphone, oxycodone, oxymorphone) at 20 ng/g or greater or 6-monoacetlymorphine at 10 ng/g or greater indicates the newborn was exposed to opiates/opioids during gestation.
Day(s) Performed
Monday through Sunday
Report Available
2 to 3 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80361
80365
G0480 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| OPATM | Opiate Confirmation, M | 69026-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 31848 | Morphine | 69027-1 |
| 31850 | Oxymorphone | 69028-9 |
| 31849 | Hydromorphone | 68541-2 |
| 31847 | Codeine | 68542-0 |
| 31852 | Oxycodone | 68543-8 |
| 31851 | Hydrocodone | 68544-6 |
| 31868 | Interpretation | 8215-6 |
| 31869 | Chain of Custody | 77202-0 |
Forms
If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.