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Test Code OXYCU Oxycodone with Metabolite Confirmation, Random, Urine

Reporting Name

Oxycodone w/metabolite Conf, U

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Detection and quantification of oxycodone, oxymorphone, noroxycodone, and noroxymorphone in urine

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)


Specimen Required


Collection Container/Tube: Plastic urine container

Submission Container/Tube: Plastic, 60-mL urine bottle

Specimen Volume: 20 mL

Collection Instructions:

1. Collect a random urine specimen.

2. Submit 20 mL in 1 plastic bottle.

3. No preservative.

Additional Information:

1. No specimen substitutions.

2. No STATS are acceptable for this procedure.

3. For situations where chain of custody is required, a Chain-of-Custody Kit (T282) is available. For chain-of-custody testing, order OXYCX / Oxycodone with Metabolite Confirmation, Chain of Custody, Urine.

4. Additional drug panels and specific requests are available. Call 800-533-1710 or 507-266-5700.

5. If urine creatinine is required or adulteration of the sample is suspected, the following test should be requested, ADULT / Adulterant Survey, Urine. For additional information, please refer to ADULT / Adulterant Survey, Urine.


Specimen Type

Urine

Specimen Minimum Volume

2.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  14 days

Reject Due To

Gross hemolysis OK
Gross icterus OK

Reference Values

Negative

Cutoff concentrations:

Oxycodone-by LC-MS/MS: 25 ng/mL

Noroxycodone-by LC-MS/MS: 25 ng/mL

Oxymorphone-by LC-MS/MS: 25 ng/mL

Noroxymorphone-by LC-MS/MS: 25 ng/mL

Interpretation

This procedure reports the total urine concentration; this is the sum of the unconjugated and conjugated forms of the parent drug.

Day(s) and Time(s) Performed

Monday through Friday, Varies

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

80365

G0480 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
OXYCU Oxycodone w/metabolite Conf, U 94304-3

 

Result ID Test Result Name Result LOINC Value
62616 Oxycodone-by LC-MS/MS 16249-5
42010 Noroxycodone-by LC-MS/MS 61425-5
35965 Oxymorphone-by LC-MS/MS 17395-5
42011 Noroxymorphone-by LC-MS/MS 90894-7
36022 Oxycodone Interpretation 19643-6

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.