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Test Code PBR Phenobarbital, Serum

Reporting Name

Phenobarbital, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring for appropriate therapeutic concentration of phenobarbital

 

Assessing compliance or toxicity

Method Name

Kinetic Interaction of Microparticles in a Solution (KIMS)


Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions:

1. Serum gel tubes should be centrifuged within 2 hours of collection.

2. Red-top tubes should be centrifuged, and the serum aliquoted into a plastic vial within 2 hours of collection.


Specimen Type

Serum

Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Gross hemolysis Reject

Reference Values

Therapeutic: 10.0-40.0 mcg/mL

Critical value: ≥60.0 mcg/mL

Interpretation

Clinical response to the drug correlates strongly with blood concentration.

 

Dosage adjustments are made after 2 weeks of therapy to achieve steady-state blood levels in the range of 20.0 to 40.0 mcg/mL for adults; 15.0 to 30.0 mcg/mL for infants and children.

 

Patients chronically administered phenobarbital usually do not experience sedation unless the blood concentration is above 40.0 mcg/mL.

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 day

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

80184

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PBR Phenobarbital, S 3948-7

 

Result ID Test Result Name Result LOINC Value
PBR Phenobarbital, S 3948-7

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Neurology Specialty Testing Client Test Request (T732)

-Therapeutics Test Request (T831)