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Test Code PLPMA Prolactin, Pituitary Macroadenoma, Serum

Reporting Name

Prolactin, Pituitary Macroadenoma

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Quantifying prolactin in serum specimens where the high-dose hook effect is suspected (eg, presence of pituitary tumor with symptoms of prolactinoma, and lower than expected serum prolactin concentration)

Method Name

Electrochemiluminescent Immunoassay


Ordering Guidance


For initial patient assessment; order PRL / Prolactin, Serum as the screening test.



Necessary Information


Patient's age and sex are required.



Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Type

Serum

Specimen Minimum Volume

1.75 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  90 days
  Ambient  24 hours

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK

Reference Values

Males

<18 years: not established

≥18 years: 4.0-15.2 ng/mL

 

Females:

<18 years: not established

≥18 years: 4.8-23.3 ng/mL 

Interpretation

If no high-dose hook effect is observed, the following report comment will be included with the prolactin result: 10-, 100-, and 400-fold dilutions produced results consistent with the absence of high-dose hook effect. Total prolactin was measured using the Roche Cobas e immunoassay analyzer.

 

If a high-dose hook effect is observed, which is demonstrated by significantly increasing concentrations of prolactin obtained after dilution of the serum, an interpretive comment will be included with the prolactin result.

 

The Roche Cobas Prolactin II assay should demonstrate no high-dose hook effect at prolactin concentrations up to approximately 12,500 ng/mL).

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 to 2 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

84146

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PLPMA Prolactin, Pituitary Macroadenoma 20568-2

 

Result ID Test Result Name Result LOINC Value
PRLR Prolactin, S 20568-2
CMT89 Comment 48767-8

Forms

If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.

Testing Algorithm

A pituitary adenoma should be identified by imaging studies prior to ordering this test.