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Test Code POSA Posaconazole, Serum

Reporting Name

Posaconazole, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring posaconazole therapy

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Collection Instructions: Within 2 hours of collection, centrifuge, and aliquot serum into plastic vial.


Specimen Type

Serum Red

Specimen Minimum Volume

0.6 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

>700 ng/mL (trough)

Interpretation

Levels greater than 700 ng/mL (0.7 mcg/mL) have been suggested for prophylaxis.

 

Levels greater than or equal to 1250 ng/mL (1.25 mcg/mL) were shown to be optimal in a salvage trial for treatment of invasive Aspergillus infections.

 

A toxic range has not been established.

Day(s) Performed

Monday through Saturday

Report Available

2 to 5 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80187

LOINC Code Information

Test ID Test Order Name Order LOINC Value
POSA Posaconazole, S 53731-6

 

Result ID Test Result Name Result LOINC Value
89591 Posaconazole, S 53731-6

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.