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HelpTest Code PSYCF Psychosine, Spinal Fluid
Reporting Name
Psychosine, CSFPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Aiding in the biochemical diagnosis of Krabbe disease using cerebrospinal fluid specimens
Follow-up of individuals affected with Krabbe disease
Follow-up testing after an abnormal newborn screening result for Krabbe disease
Monitoring individuals at risk to develop late onset Krabbe disease
Monitoring individuals with Krabbe disease after hematopoietic stem cell transplantation
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Ordering Guidance
This test is recommended as a diagnostic or monitoring test when spinal fluid is collected primarily to determine protein content in a patient at risk of or monitored for the development of signs of Krabbe disease.
An additional and less invasive diagnostic or monitoring test is measurement of psychosine in red blood cells; see PSYR / Psychosine, Whole Blood.
Shipping Instructions
Send on dry ice. Avoid freeze thaw cycles.
Necessary Information
1. Patient's age is required.
2. Date of hematopoietic stem cell transplantation (HSCT), if performed.
Specimen Required
Container/Tube: Sterile vial.
Specimen Volume: 0.15 mL
Collection Instructions: Do not aliquot.
Specimen Type
CSFSpecimen Minimum Volume
0.1 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| CSF | Frozen | 7 days |
Reject Due To
| Gross hemolysis | Reject |
Reference Values
Normal < 0.04 nmol/L
Interpretation
An elevation of psychosine is indicative of Krabbe disease or saposin A cofactor deficiency.
Day(s) Performed
Tuesday, Thursday
Report Available
3 to 7 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
82542
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PSYCF | Psychosine, CSF | 93686-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 606150 | Interpretation (PSYCF) | 59462-2 |
| 606146 | Psychosine, CSF | 93686-4 |
| 605158 | Reviewed By | 18771-6 |
Forms
If not ordering electronically, complete, print, and send a Biochemical Genetics Test Request (T798) with the specimen.