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HelpTest Code PYRC Pyruvate, Spinal Fluid
Reporting Name
Pyruvic Acid, CSFPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Investigating possible disorders of mitochondrial metabolism, when used in conjunction with cerebrospinal fluid lactate, collected at the same time, to determine the lactate-to-pyruvate (L:P) ratio
Evaluating patients with neurologic dysfunction and normal blood L:P ratios
Method Name
Spectrophotometry (SP)
Additional Testing Requirements
This test does not calculate the lactate:pyruvate ratio. To obtain this information, both this test and LASF1 / Lactic Acid, Spinal Fluid must be ordered. The ratio can be calculated from the results obtained from these tests.
Specimen Required
Specimen Type: Spinal fluid
Container/Tube: Sterile vial
Specimen Volume: 0.6 mL
Collection Instructions: Send specimen from vial 4.
Specimen Type
CSFSpecimen Minimum Volume
0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| CSF | Refrigerated (preferred) | 7 days | |
| Frozen | 14 days | ||
| Ambient | 7 days |
Reject Due To
| Gross hemolysis | Reject |
Reference Values
0.06-0.19 mmol/L
Interpretation
An elevated lactate-to-pyruvate (L:P) ratio may indicate inherited disorders of the respiratory chain complex, tricarboxylic acid cycle disorders and pyruvate carboxylase deficiency. Respiratory chain defects usually result in L:P ratios above 20.
A low L:P ratio (disproportionately elevated pyruvic acid) may indicate an inherited disorder of pyruvate metabolism. Defects of the pyruvate dehydrogenase complex result in L:P ratios below 10.
The L:P ratio is characteristically normal in other patients. An artifactually high ratio can be found in acutely ill patients.
Day(s) Performed
Monday, Wednesday
Report Available
4 to 8 daysTest Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
84210
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| PYRC | Pyruvic Acid, CSF | 14122-6 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 83356 | Pyruvic Acid, CSF | 14122-6 |
Forms
1. Biochemical Genetics Patient Information (T602)
2. If not ordering electronically, complete, print, and send a Biochemical Genetics Test Request (T798) with the specimen.
Special Instructions
Testing Algorithm
For more information see: Epilepsy: Unexplained Refractory and/or Familial Testing Algorithm