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Test Code RAMIK Amikacin, Random, Serum

Reporting Name

Amikacin, Random, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring adequacy of blood concentration during amikacin therapy

Method Name

Kinetic Interaction of Microparticles in Solution (KIMS)


Ordering Guidance


Specimen for a peak level should be collected 30 to 60 minutes after last dose; order PAMIK / Amikacin, Peak, Serum.

 

Specimen for a trough level should be collected immediately before next scheduled dose; order TAMIK / Amikacin, Trough, Serum.



Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions:

1. Serum gel tubes should be centrifuged within 2 hours of collection.

2. Red-top tubes should be centrifuged, and the serum aliquoted into a plastic vial within 2 hours of collection.


Specimen Type

Serum

Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  28 days
  Ambient  72 hours

Reject Due To

Gross hemolysis Reject

Reference Values

Peak: 20.0-35.0 mcg/mL

Toxic peak: >40.0 mcg/mL

Trough: <8.0 mcg/mL

Toxic trough:>10.0 mcg/mL

Interpretation

For conventional (nonpulse) dosing protocols, clinical effects may not be achieved if the peak serum concentration is <20.0 mcg/mL. Toxicity may occur if, for prolonged periods of time, peak serum concentrations are maintained >35.0 mcg/mL, or trough concentrations are maintained at >10.0 mcg/mL.

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 day

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

80150 

LOINC Code Information

Test ID Test Order Name Order LOINC Value
RAMIK Amikacin, Random, S 35669-1

 

Result ID Test Result Name Result LOINC Value
RAMIK Amikacin, Random, S 35669-1

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.