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Test Code RSCOC Coccidioides Antibody Reflex, Complement Fixation and Immunodiffusion, Serum

Reporting Name

Coccidioides Ab, CompF/ImmDiff,S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Detection of antibodies to Coccidioides species

Method Name

Only orderable as a reflex. For more information see COXIS / Coccidioides Antibody Screen with Reflex, Serum.

 

Complement Fixation (CF)/Immunodiffusion (ID)


Ordering Guidance


 



Specimen Required


Only orderable as a reflex. For more information see COXIS / Coccidioides Antibody Screen with Reflex, Serum.


Specimen Type

Serum

Specimen Minimum Volume

1.2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reject Due To

All specimens will be evaluated at Mayo Clinic Laboratories for test suitability.

Reference Values

Only orderable as a reflex. For more information see COXIS / Coccidioides Antibody Screen with Reflex, Serum.

 

COMPLEMENT FIXATION:

Negative

If positive, results are titered.

 

IMMUNODIFFUSION:

Negative

Results are reported as positive, negative, or equivocal.

Interpretation

Complement Fixation:

Titer results of 1:2 or higher may suggest active disease; however, titers may persist for months after infection has resolved. Increasing complement fixation (CF) titer results in serial specimens are considered diagnostic of active disease.

 

Immunodiffusion:

The presence of IgM antibody may be detectable within 2 weeks after the onset of symptoms; however, antibody may be detected longer than 6 months after infection.

 

The presence of IgG antibody parallels the CF antibody and may suggest an active or a recent asymptomatic infection with Coccidioides immitis/posadasii; however, antibodies may persist after the infection has resolved.

 

An equivocal result (a band of nonidentity) cannot be interpreted as significant for a specific diagnosis. However, this may be an indication that a patient should be followed serologically.

 

Over 90% of primary symptomatic cases will be detected by combined immunodiffusion (ID) and CF testing.

Day(s) Performed

Monday through Friday

Report Available

4 to 7 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86635 x 3

LOINC Code Information

Test ID Test Order Name Order LOINC Value
RSCOC Coccidioides Ab, CompF/ImmDiff,S 26625-4

 

Result ID Test Result Name Result LOINC Value
35942 Coccidioides Ab, CompF,S 33379-9
35943 Coccidioides, IgG, ImmDiff,S 46182-2
35944 Coccidioides, IgM, ImmDiff,S 46183-0