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Test Code SCERA Saccharomyces cerevisiae Antibody, IgA, Serum

Reporting Name

Saccharomyces cerevisiae Ab, IgA, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Measuring IgA anti-Saccharomyces cerevisiae antibodies as a part of a profile to aid in distinguishing between ulcerative colitis and Crohn disease in patients for whom the specific diagnosis is unclear based on endoscopic, pathologic, and imaging evaluations

 

This test is not useful for determining the extent of disease in patients with inflammatory bowel disease or determining the response to disease-specific therapy including surgical resection of diseased intestine

Method Name

Enzyme-Linked Immunosorbent Assay (ELISA)


Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Specimen Type

Serum

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 21 days
  Frozen  21 days

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject
Gross icterus OK
Heat-treated specimen Reject

Reference Values

Negative: <20.0 RU/mL

Positive: ≥20.0 RU/mL

Reference values apply to all ages.

Interpretation

The presence of antineutrophil cytoplasmic antibodies (ANCA) in the absence of IgA and IgG anti-Saccharomyces cerevisiae antibodies (ASCA) is consistent with the diagnosis of ulcerative colitis; the presence of IgA and IgG ASCA in the absence of ANCA is consistent with Crohn disease.

Day(s) Performed

Tuesday, Thursday

Report Available

2 to 4 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86671

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SCERA Saccharomyces cerevisiae Ab, IgA, S 47320-7

 

Result ID Test Result Name Result LOINC Value
SCERA Saccharomyces cerevisiae Ab, IgA, S 47320-7