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Test Code TCGBM T-Cell Receptor Gene Rearrangement, PCR, Bone Marrow

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Method Name

DNA Extracted for Analysis/Polymerase Chain Reaction (PCR)

Reporting Name

T Cell Receptor Gene Rearrange, BM


Shipping Instructions


Specimen must arrive within 7 days (168 hours) of collection.



Necessary Information


Include relevant clinical information and cytogenetics results, if available.



Specimen Required


Container/Tube:

Preferred: EDTA (lavender top)

Acceptable: ACD (yellow top)

Specimen Volume: 2 mL

Collection Instructions:

1. Invert several times to mix bone marrow.

2. Send specimen in original tube.


Specimen Type

Bone Marrow

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Bone Marrow Ambient (preferred) 7 days
  Refrigerated  7 days

Reject Due To

Gross hemolysis Reject
Other Moderately to severely clotted

Reference Values

An interpretive report will be provided.

Positive, negative, or indeterminate for a clonal T-cell population

Day(s) and Time(s) Performed

Monday through Friday

Test Classification

This test was developed using an analyte specific reagent. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

81340-TCB (T cell antigen receptor, beta) (eg, leukemia and lymphoma), gene rearrangement analysis to detect abnormal clonal population(s); using amplification methodology (eg, PCR)

81342-TCG@ (T cell receptor, gamma) (eg, leukemia and lymphoma), gene rearrangement analysis, evaluation to detect abnormal clonal population(s)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TCGBM T Cell Receptor Gene Rearrange, BM In Process

 

Result ID Test Result Name Result LOINC Value
19957 Final Diagnosis: 22637-3

Useful For

Determining whether a T-cell population is polyclonal or monoclonal

Testing Algorithm

See Bone Marrow Staging for Known or Suspected Malignant Lymphoma Algorithm in Special Instructions.

Interpretation

An interpretive report will be provided.

 

Results will be characterized as positive, negative, or indeterminate for a clonal T-cell population.

 

In the appropriate clinicopathologic setting, a monoclonal result is associated with a neoplastic proliferation of T cells (see Cautions).

Forms

1. Hematopathology Patient Information (T676) in Special Instructions

2. If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.