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Test Code TIS Titanium, Serum

Reporting Name

Titanium, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring metallic prosthetic implant wear

Method Name

Triple-Quadrupole Inductively Coupled Plasma Mass Spectrometry (ICP-MS)


Specimen Required


Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metal tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for at least 96 hours.

Supplies:

-Metal Free Specimen Vial (T173)

-Metal Free B-D Tube (No Additive), 6 mL (T184)

Collection Container/Tube: Plain, royal blue-top Vacutainer plastic trace element blood collection tube

Submission Container/Tube: 7-mL Metal-free, screw-capped, polypropylene vial

Specimen Volume: 1.2 mL

Collection Instructions:

1. Allow specimen to clot for 30 minutes; then centrifuge the specimen to separate serum from the cellular fraction.

2. Remove the stopper. Carefully pour specimen into a metal-free, polypropylene vial, avoiding transfer of the cellular components of blood. Do not insert a pipet into the serum to accomplish transfer, and do not ream the specimen with a wooden stick to assist with serum transfer.

3. See Metals Analysis Specimen Collection and Transport for complete instructions.


Specimen Type

Serum

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days METAL FREE
  Frozen  28 days METAL FREE
  Ambient  7 days METAL FREE

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

<2 ng/mL

Interpretation

Prosthesis wear is known to result in increased circulating concentration of metal ions. In the absence of an implant, circulating titanium is below 1 ng/mL. Modest increase (1.0-3.0 ng/mL) in serum titanium concentration is evident with a prosthetic device in good condition. Serum concentrations above 10 ng/mL in a patient with titanium-based implant suggest prosthesis wear.

 

Increased serum titanium concentration in the absence of corroborating clinical information does not independently predict prosthesis wear or failure.

Day(s) Performed

Wednesday

Report Available

2 to 8 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83018

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TIS Titanium, S 8244-6

 

Result ID Test Result Name Result LOINC Value
89367 Titanium, S 8244-6