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Test Code TMP Trimethoprim, Serum

Reporting Name

Trimethoprim, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring trimethoprim therapy to ensure drug absorption, clearance, or compliance

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (gel tubes/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Serum for a peak level should be collected at least 60 minutes after a dose.

2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.


Specimen Type

Serum Red

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Reference Values

>2.0 mcg/mL (Peak)

Interpretation

Most patients will display peak steady state serum concentrations of more than 2.0 mcg/mL when the specimen is collected at least 1 hour after an oral dose. Target concentrations may be higher depending on the intent of therapy.

Day(s) Performed

Monday, Thursday

Report Available

2 to 5 days

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80299

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TMP Trimethoprim, S 11005-6

 

Result ID Test Result Name Result LOINC Value
80146 Trimethoprim, S 11005-6

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.