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Test Code TRSF Transferrin, Serum

Reporting Name

Transferrin, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Screening for chronic iron overload diseases, particularly hereditary hemochromatosis

Method Name

Immunoturbidimetric Assay


Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.6 mL

Collection Instructions:

1. Serum gel tubes should be centrifuged within 2 hours of collection.

2. Red-top tubes should be centrifuged, and the serum aliquoted into a plastic vial within 2 hours of collection.


Specimen Type

Serum

Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  180 days
  Ambient  7 days

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK

Reference Values

200-360 mg/dL

Interpretation

Serum iron, total iron-binding capacity (TIBC), and percent saturation are useful only in screening for chronic iron overload diseases, particularly hereditary hemochromatosis. Although serum iron, TIBC, and percent saturation are widely used for the diagnosis of iron deficiency, serum ferritin is a much more sensitive and reliable means of demonstrating iron deficiency.

 

In hereditary hemochromatosis, serum iron is usually above 150 mcg/dL and percent saturation exceeds 60%.

 

In advanced iron overload states, the percent saturation often exceeds 90%.

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 3 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

84466

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TRSF Transferrin, S 3034-6

 

Result ID Test Result Name Result LOINC Value
TRSF Transferrin, S 3034-6

Forms

If not ordering electronically, complete, print, and send a Benign Hematology Test Request Form (T755) with the specimen.