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Test Code ULFA Cryptococcus Antigen Screen, Lateral Flow Assay, Random, Urine

Reporting Name

Cryptococcus Ag Screen, LFA, U

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Aiding in the diagnosis of infection with Cryptococcus neoformans or Cryptococcus gattii

 

This test should not be used as a test of cure.

 

This test should not be used as a screening procedure for the general population.

Method Name

Lateral Flow Assay (LFA)


Specimen Required


Supplies: Urine Tubes, 10 mL (T068)

Submission Container/Tube: Plastic, 10-mL urine tube

Specimen Volume: 1 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.


Specimen Type

Urine

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  14 days

Reject Due To

Gross hemolysis Reject
Turbid; Colored Reject

Reference Values

Negative

Reference values apply to all ages.

Interpretation

The presence of cryptococcal antigen (CrAg) in any body fluid is strongly suggestive of infection with Cryptococcus neoformans or Cryptococcus gattii.

 

Declining titer results are suggestive of clinical response to therapy. However, monitoring CrAg titers should not be used as a test of cure, as low-level titers may persist for extended periods of time following appropriate therapy and disease resolution.

 

In addition to testing for CrAg, patients with presumed disease due to C neoformans or C gattii should have appropriate clinical specimens (eg, blood, bronchoalveolar lavage fluid) submitted for routine smear and fungal culture.

Day(s) Performed

Monday through Friday

Report Available

1 to 4 days

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

87899

87899 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ULFA Cryptococcus Ag Screen, LFA, U 16693-4

 

Result ID Test Result Name Result LOINC Value
604095 Cryptococcus Ag Screen, LFA, U 16693-4

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
ULFAT Cryptococcus Ag Titer, LFA, U No No

Testing Algorithm

If this screen is positive, the antigen titer will be performed at an additional charge.