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Test Code VANRA Vancomycin, Random, Serum

Reporting Name

Vancomycin, Random, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring adequacy of drug concentration during vancomycin therapy whenever a specimen is submitted or collected without collection timing information

Method Name


Specimen Type

Serum Red

Advisory Information

In addition to this random assay, both peak level and trough level testing are available.

1. Serum for a peak level should be drawn 1 hour after completion of dose (order VANPA / Vancomycin, Peak, Serum).

2. Serum for a trough level should be drawn no more than 30 minutes prior to next dose (order VANTA / Vancomycin, Trough, Serum).

Specimen Required

Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot within 2 hours of collection.

Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 14 days
  Frozen  365 days
  Ambient  48 hours

Reject Due To

Gross hemolysis Reject

Reference Values


Therapeutic: 10.0-20.0 mcg/mL



Therapeutic: 20.0-45.0 mcg/mL


Trough levels correlate better with efficacy than peak levels, with target trough levels of 10.0 and 20.0 mcg/mL, depending on the type of infection.


Peak levels are not recommended for monitoring, except in select circumstances such as when performing pharmacokinetic analyses (eg, area under the curve: AUC determinations). Typical peak levels are between 20.0 and 45.0 mcg/mL.


These levels are consistent with Mayo Clinic Antimicrobial Therapy Guidelines.

Day(s) and Time(s) Performed

Monday through Sunday; Continuously

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
VANRA Vancomycin, Random, S 20578-1


Result ID Test Result Name Result LOINC Value
VANRA Vancomycin, Random, S 20578-1


If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.