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Test Code VANRA Vancomycin, Random, Serum

Reporting Name

Vancomycin, Random, S

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring adequacy of drug concentration during vancomycin therapy whenever a specimen is submitted or collected without collection timing information

Method Name

Immunoassay


Ordering Guidance


In addition to this random assay, both peak level and trough level testing are available.

1. Serum for a peak level should be drawn 1 hour after completion of dose; order VANPA / Vancomycin, Peak, Serum.

2. Serum for a trough level should be drawn no more than 30 minutes prior to next dose; order VANTA / Vancomycin, Trough, Serum.



Specimen Required


Collection Container/Tube: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum within 2 hours of collection.


Specimen Type

Serum Red

Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Refrigerated (preferred) 14 days
  Frozen  365 days
  Ambient  48 hours

Reject Due To

Gross hemolysis Reject

Reference Values

VANCOMYCIN, TROUGH

Therapeutic: 10.0-20.0 mcg/mL

 

VANCOMYCIN, PEAK

Therapeutic: 20.0-45.0 mcg/mL

Interpretation

Trough levels correlate better with efficacy than peak levels, with target trough levels of 10.0 and 20.0 mcg/mL, depending on the type of infection.

 

Peak levels are not recommended for monitoring, except in select circumstances such as when performing pharmacokinetic analyses (eg, area under the curve: AUC determinations). Typical peak levels are between 20.0 and 45.0 mcg/mL.

 

These levels are consistent with Mayo Clinic Antimicrobial Therapy Guidelines.

Day(s) Performed

Monday through Sunday

Report Available

Same day/1 to 2 days

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

80202

LOINC Code Information

Test ID Test Order Name Order LOINC Value
VANRA Vancomycin, Random, S 20578-1

 

Result ID Test Result Name Result LOINC Value
VANRA Vancomycin, Random, S 20578-1

Forms

If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.