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HelpTest Code VITB3 Vitamin B3 and Metabolites, Plasma
Specimen Required
Patient Preparation: Fasting 4 to 8 hours preferred
Supplies: Sarstedt Aliquot Tube 5 mL (T914)
Collection Container/Tube:
Preferred: Lavender top (K2 EDTA)
Acceptable: K3 EDTA
Submission Container/Tube: Plastic vial
Specimen Volume: 1.5 mL
Collection Instructions: Centrifuge and aliquot plasma into a plastic vial within 2 hours of collection.
Useful For
Assisting in the diagnosis of suspected vitamin B3 deficiency or toxicity
May be useful in determining response to therapy
Method Name
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Reporting Name
Vitamin B3 and Metabolites, PSpecimen Type
Plasma EDTASpecimen Minimum Volume
0.75 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Plasma EDTA | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 21 days |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | OK |
Reference Values
Nicotinic Acid (Niacin) Cutoff: <5.0 ng/mL
Nicotinamide: 5.0-48.0 ng/mL
Nicotinuric Acid Cutoff: <5.0 ng/mL
Interpretation
Nicotinamide concentrations below the established reference range indicate a deficiency.
Niacin or nicotinamide concentrations that exceed the upper reference range substantially suggest potential toxicity in patients with excessive supplement intake or under niacin treatment for hypercholesterinemia.
Day(s) Performed
Monday, Tuesday, Thursday, Friday
Report Available
2 to 4 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
84591
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| VITB3 | Vitamin B3 and Metabolites, P | 102102-1 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 609493 | Nicotinic Acid (Niacin) | 18244-4 |
| 609494 | Nicotinamide | 56961-6 |
| 609495 | Nicotinuric Acid | 72306-4 |